Premium
Synthesis of Ethyl 2‐Amino‐4‐benzoyl‐5‐oxo‐5,6‐dihydro‐4 H ‐pyrano[3,2‐ c ]quinoline‐3‐carboxylates by a One‐pot, Three‐Component Reaction in the Presence of TPAB
Author(s) -
Poursattar Marjani Ahmad,
Khalafy Jabbar,
Farajollahi Ayda
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3404
Subject(s) - chemistry , quinoline , ethyl cyanoacetate , bromide , catalysis , proton nmr , elemental analysis , component (thermodynamics) , yield (engineering) , carbon 13 nmr , medicinal chemistry , organic chemistry , malononitrile , physics , materials science , metallurgy , thermodynamics
In this research, in order to synthesize a series of ethyl 2‐amino‐4‐benzoyl‐5‐oxo‐5,6‐dihydro‐4 H ‐pyrano[3,2‐ c ]quinoline‐3‐carboxylates, a green and an efficient method is proposed through one‐pot three‐component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4‐hydroxyquinolin‐2(1 H )‐one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, 1 H‐NMR, and 13 C‐NMR spectral data and elemental analysis.