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Retracted: Synthesis, Molecular Properties, and Biological Evaluation of Hybrid 1,2,3‐Triazolylpolyaza Heterocyclic Compounds
Author(s) -
Dasari Srinivasa Rao,
Tondepu Subbaiah,
Vadali Lakshmana Rao,
Ganivada Mutyala Naidu,
Seelam Nareshvarma
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3395
Subject(s) - chemistry , lipinski's rule of five , combinatorial chemistry , stereochemistry , biological activity , computational biology , molecule , cell culture , cancer cell lines , cancer , cancer cell , biochemistry , organic chemistry , in vitro , gene , medicine , genetics , biology , in silico
In this research article, a highly efficient, cost‐effective synthesis of various hybrid molecules possessing 1,2,3‐triazolyltetrazoles and evaluation of their biological activity have been addressed. The structure elucidation of these new library hybrid molecules has been carried out by IR, 1 H NMR, 13 C NMR, and mass spectral analysis. The compounds have been screened for their anticancer activity against human colon cancer cell line Colo‐205 and human lung cancer cell line HOP‐205, and the results attest that most of the compounds have shown very good therapeutic nature. In particular, compounds 3d , 3j , 6a , and 6e were more cytotoxic than Adriamycin against all tested human cancer cell lines with 68%, 101.8%, 94%, and 104.5% growth, respectively. In the present investigation, a series of 3a – j and 6a – h were subjected to molecular properties prediction, drug likeness by Molinspiration, and toxicity risks by Molsoft software programs. All the 18 analogues were chosen on the basis of Lipinski “Rule of five” for the synthesis, screening their antibacterial and anticancer as oral bioavailable drugs/leads.