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Design, Synthesis, and Structural Elucidation of New Pyridine and Thienopyridine Derivatives
Author(s) -
Elsayed Mohamed A.,
Abdel Hafez Naglaa A.,
Elshahawi Manal M.,
Ali Korany A.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3392
Subject(s) - chemistry , malononitrile , phenacyl bromide , pyridine , thienopyridine , ethyl chloroacetate , combinatorial chemistry , imidazopyridine , bromide , organic chemistry , medicinal chemistry , hydrate , catalysis , biochemistry , aspirin , clopidogrel
New series of 3‐cyanopyridine scaffolds were prepared from the reaction of 3‐(4‐bromophenyl)‐1‐(3,4‐dimethoxyphenyl)prop‐2‐en‐1‐one with active nitriles, including malononitrile and 2‐cyanothioacetamide. The newly prepared 6‐(4‐bromophenyl)‐4‐(3,4‐dimethoxyphenyl)‐2‐thioxo‐1,2‐dihydropyridine‐3‐carbonitrile was used as a scaffold for the preparation of new series of condensed thienopyridines by its reactions with active halo compounds, namely, ethyl chloroacetate, chloroacetonitrile, phenacyl bromide, chloroacetone, and 2‐chloro‐ N ‐arylacetamide. The structures of the synthesized compounds were elucidated by the elemental analysis, spectral data and chemically by their preparations with other pathways.