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Regioselective Synthesis of 1,6‐Dihydropyrrolo[2,3‐ g ]indazole Derivatives via Three‐Component Domino Reaction
Author(s) -
Chen DongSheng,
Li Li,
Liu JiaYan,
Wei Ming,
Chu RuoHan,
An Qiong,
Zhang Ming
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3372
Subject(s) - chemistry , indazole , regioselectivity , cascade reaction , amine gas treating , acetic acid , domino , combinatorial chemistry , catalysis , ethanol , component (thermodynamics) , organic chemistry , reaction conditions , medicinal chemistry , physics , thermodynamics
A series of 1,6‐dihydropyrrolo[2,3‐ g ]indazole derivatives have been obtained by a three‐component domino reaction of 1 H ‐indazol‐6‐amine, arylglyoxal monohydrates, and cyclic 1,3‐dicarbonyl compounds in ethanol medium at 60°C catalyzed by acetic acid. The notable features of this synthesis are excellent regioselectivity, operational simplicity, relative mild reaction conditions, and good yields.