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An Efficient Method for the One‐pot Synthesis of 4‐Phenyl‐hydrazinyl Thiazole Derivatives Using Nano‐SiO 2
Author(s) -
Gholami Sahar,
Mokhtary Masoud
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3371
Subject(s) - chemistry , thiazole , environmentally friendly , one pot synthesis , phenacyl , phenacyl bromide , reaction conditions , nano , ethanol , organic chemistry , chloride , combinatorial chemistry , catalysis , chemical engineering , engineering , ecology , biology
One‐pot synthesis of 4‐phenyl‐hydrazinyl thiazole derivatives was developed by three‐component reaction of various ketones, phenacyl chloride, and thiosemicarbazid in the presence of nano‐SiO 2 in ethanol at reflux conditions. The products formed in excellent yields over short reaction times under an environmentally friendly condition.