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Acid Catalyzed One‐pot Three‐component Biginelli‐type Synthesis of Some New Symmetrical Bis 3,4‐dihydropyrimidin‐2(1 H )‐ones/thiones
Author(s) -
Gülten Şirin,
Arslan Ezgi
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3367
Subject(s) - chemistry , thiourea , ethyl acetoacetate , amide , catalysis , urea , aldehyde , biginelli reaction , organic chemistry , ether , ethanol , medicinal chemistry
Biologically important 21 new symmetrical bis 3,4‐dihydropyrimidin‐2(1 H )‐ones/thiones were synthesized by reacting 4,4′‐diaminodiphenyl ether/4,4′‐ethylenedianiline with tert ‐butyl acetoacetate to produce diphenyl ether‐bridged bis β‐keto amide/diphenyl ethane‐bridged bis β‐keto amide then treated with urea or thiourea and an appropriate aldehyde with either a catalytic amount of p‐TSA·H 2 O or conc. HCl in ethanol afforded the title compounds.