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γ‐Valerolactone as a Promising Bio‐Compatible Media for One‐Pot Synthesis of Spiro[indoline‐3,4'‐pyrano[3,2‐ c ]chromene Derivatives
Author(s) -
Diwan Furqan,
Farooqui Mazahar
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3351
Subject(s) - isatin , indoline , chemistry , coumarin , yield (engineering) , methylene , combinatorial chemistry , organic chemistry , one pot synthesis , catalysis , materials science , metallurgy
A general, highly efficient, and green protocol for the synthesis of biologically important spiro[indoline‐3,4′‐pyrano[3,2‐ c ]chromene derivatives is developed by one‐pot, three‐component approach involving substituted isatin, active methylene group, and 4‐hydroxy coumarin. This report describes the use of γ‐valerolactone as a green reaction media for a variety of substrates. The advantageous features of this methodology are the environmentally benign character, operational simplicity, high yield processing (91–96%), easy handling, and the reaction medium can be recycled and reused several times without significant loss of its efficiency.