Premium
Silica‐Supported P 2 O 5 as an Efficient Heterogeneous Catalyst for the One Pot Synthesis of 3‐Amino‐imidazo[2,1‐ b ](1,3)benzothiazole under Green Conditions
Author(s) -
Khan Takallum,
Yadav Ritu
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3334
Subject(s) - chemistry , benzothiazole , catalysis , isocyanide , yield (engineering) , solid acid , condensation reaction , one pot synthesis , indole test , aryl , solvent , condensation , fourier transform infrared spectroscopy , organic chemistry , combinatorial chemistry , heterogeneous catalysis , melting point , carbon 13 nmr , chemical engineering , materials science , alkyl , physics , engineering , metallurgy , thermodynamics
The new approach involving the solid supported catalyst for the formation of C–N bond followed by cyclization has been reported. In this work we have reported a facile, efficient, and environment‐friendly protocol for the synthesis of some new 3‐amino‐imidazo[2,1‐ b ](1,3)benzothiazole derivatives by one‐pot condensation of 2‐aminobenzothiazole, indole‐3‐carbaldehyde, and aryl isocyanide in the presence of silica‐supported P 2 O 5 as a heterogeneous solid acid catalyst. The reaction was performed using conventional method under green conditions. The present approach offers the advantages of simple methodology, inexpensive acid catalyst, short reaction time, easy work up with excellent yield, simple purification and use of green solvent. All the newly synthesized compounds were characterized in details using physical and chemical techniques such as melting point, 1 H NMR, 13 C NMR, and FTIR spectroscopy.