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Efficient Synthesis of Pyridin‐2(1 H )‐ones From a Series of Readily Available Enaminones Under Mild Conditions
Author(s) -
Gao Baochang,
Sun Yufeng,
Wang Jun,
Zu Liwu,
Zhang Xu,
Liu Wenbin
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3333
Subject(s) - chemistry , malononitrile , dimethylformamide , ring (chemistry) , combinatorial chemistry , ethanol , organic chemistry , reaction conditions , solvent , catalysis
A facile and efficient synthesis of substituted pyridin‐2(1 H )‐ones has been developed by the reaction of readily available enaminones with malononitrile in ethanol at room temperature in yields of 85–95%. This protocol, which combines construction and modification of the pyridin‐2(1 H )‐ones ring under Vilsmeier conditions (dimethylformamide/POCl 3 ), increases the structural diversity of the final products from readily available materials.