Synthesis of some New Dihydropyrimidines Derivatives by Cyclization of Polarized Unsaturated Systems | Zendy

Ragab Islam | Zendy; Selim Yasser A. | Zendy; Abd ElAzim Mohamed H. M. | Zendy

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Synthesis of some New Dihydropyrimidines Derivatives by Cyclization of Polarized Unsaturated Systems

Author(s) -

Ragab Islam,

Selim Yasser A.,

Abd ElAzim Mohamed H. M.

Publication year - 2018

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3332

Subject(s) - chemistry , chloroacetic acid , thiourea , acetamide , cyanoacetamide , pyridine , urea , medicinal chemistry , organic chemistry

Reaction of benzylidene cyanoester 1 with thiosemicarbazide, cyanoacetamide, urea and thiourea was resulted in triazepine 2 , pyridine 5 , oxopyrimidine 6 , and thiooxopyrimidine 8 , respectively. Triazepine 2 was reacted with chloroacetic acid and/or chloroacetamide to give thiazolotriazepine 3 and acetamide 4 . Reaction of thiopryrimidine 8 with hydrogeneperoxide affording pyrimidins 9 and with chloroacetic acid and chloroacetamide yielded thiazolopyrimidine benzylidene 10 and acetamide 11 , while the reaction of 8 with benzylidene derivatives yielded pyrimidopyrimidine 16 and 17 .

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