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Synthesis of some New Dihydropyrimidines Derivatives by Cyclization of Polarized Unsaturated Systems
Author(s) -
Ragab Islam,
Selim Yasser A.,
Abd ElAzim Mohamed H. M.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3332
Subject(s) - chemistry , chloroacetic acid , thiourea , acetamide , cyanoacetamide , pyridine , urea , medicinal chemistry , organic chemistry
Reaction of benzylidene cyanoester 1 with thiosemicarbazide, cyanoacetamide, urea and thiourea was resulted in triazepine 2 , pyridine 5 , oxopyrimidine 6 , and thiooxopyrimidine 8 , respectively. Triazepine 2 was reacted with chloroacetic acid and/or chloroacetamide to give thiazolotriazepine 3 and acetamide 4 . Reaction of thiopryrimidine 8 with hydrogeneperoxide affording pyrimidins 9 and with chloroacetic acid and chloroacetamide yielded thiazolopyrimidine benzylidene 10 and acetamide 11 , while the reaction of 8 with benzylidene derivatives yielded pyrimidopyrimidine 16 and 17 .