Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles via 1,3‐Dipolar Cycloaddition/C–N Coupling of Propargyl Alcohols/amines and Aryl Azides | Zendy

Bakherad Mohammad | Zendy; Ghalenoei Ahmad Kakavand | Zendy; Keivanloo Ali | Zendy

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Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles via 1,3‐Dipolar Cycloaddition/C–N Coupling of Propargyl Alcohols/amines and Aryl Azides

Author(s) -

Bakherad Mohammad,

Ghalenoei Ahmad Kakavand,

Keivanloo Ali

Publication year - 2018

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3325

Subject(s) - chemistry , cycloaddition , propargyl , aryl , propargyl alcohol , 1,3 dipolar cycloaddition , catalysis , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl

1,4‐Disubstituted 1,2,3‐triazoles are prepared through the 1,3‐dipolar cycloaddition of propargyl (alcohols/amines) and aryl azides in the presence of a mixture of Cu(OAc) 2 .H 2 O and NaAs as the catalyst. This method offers the advantages of mild experimental conditions, operational simplicity, and high‐to‐excellent reaction yields.

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