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Synthesis of 4‐Methylimidazole‐2‐Carboxylic Acid
Author(s) -
Wang Xianheng,
Zhao Changkuo,
Gao Lei,
Zhou Yiqi,
Xu Lang
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3321
Subject(s) - chemistry , yield (engineering) , reagent , acylation , carboxylic acid , hydrolysis , solvent , organic chemistry , combinatorial chemistry , catalysis , materials science , metallurgy
4‐Methylimidazole‐2‐carboxylic acid was synthesized from 4‐methylimidazole with a total yield of 65% over four steps including an N‐benzyl protection, acylation, debenzylation, and ester hydrolysis. The solvent, base, temperature, and reaction time are optimized for this method. This efficient, convenient, and low‐cost protocol uses inexpensive reagents in each step to obtain 4‐methylimidazole‐2‐carboxylic acid in high yield.