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One‐pot, Three‐component Synthesis of a Series of New Bis‐pyrrolo[2,3‐ d ]pyrimidines in the Presence of TPAB under Reflux Conditions
Author(s) -
Ahmadi Sabegh Mehdi,
Khalafy Jabbar,
Etivand Nasser
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3320
Subject(s) - chemistry , dimedone , glyoxal , barbituric acid , pyrimidine , component (thermodynamics) , bromide , ethanol , medicinal chemistry , condensation , reflux , organic chemistry , stereochemistry , catalysis , physics , thermodynamics , medicine , disease , pathology
A one‐pot, three‐component reaction of 1,4‐phenylene‐bis‐glyoxal, 6‐aminouracils, and dimedone or barbituric acid derivatives in the presence of tetrapropylammonium bromide (5 mol%) in ethanol under reflux conditions gave a series of new bis‐pyrrolo[2,3‐ d ]pyrimidine derivatives in high yields.