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Thiazolidine‐4‐ones from Thiocarbohydrazides
Author(s) -
Hassan Alaa A.,
Makhlouf Maysa M.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3315
Subject(s) - chemistry , thiazolidine , regioselectivity , condensation , combinatorial chemistry , component (thermodynamics) , organic chemistry , catalysis , thermodynamics , physics
Several methods for the preparation of thiazolidin‐4‐ones from thiocarbohydrazides over the last 15 years are highlighted. Thiosemicarbazides, thiocarbohydrazides, thioamides, and hydrazinecarbothioamides as well as thioureas were used to obtain different substituted thiazolidinones under reaction conditions. Thiazolidinones can be synthesized either by a one‐pot three‐component condensation or a two‐step process. Also, the mechanism of formation, regioselectivity issues, and biological activities of different thiazolidinones were discussed.