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Synthesis and Urease Inhibition Study of Some New Quinazolinone Derivatives Bearing Triazole, Thiadiazole, and Piperazine Moiety
Author(s) -
Karaali Nesrin,
Menteşe Meltem,
Baltas Nimet,
Menteşe Emre
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3313
Subject(s) - chemistry , moiety , thiourea , quinazolinone , acetohydroxamic acid , piperazine , urease , triazole , stereochemistry , dept , 1,2,4 triazole , medicinal chemistry , nuclear chemistry , organic chemistry , urea
A new series of 2,3‐disubstituted quinazolin‐4(3 H )‐one derivatives bearing triazole and thiadiazole nucleus has been synthesized and then screened for their urease inhibition properties. All synthesized compounds showed outstanding urease inhibitory potentials with IC 50 values ranging between 0.25 ± 0.01 and 18.00 ± 0.64 μg/mL when compared with standard inhibitors thiourea (IC 50 = 15.08 ± 0.71 μg/mL) and acetohydroxamic acid (IC 50 = 21.05 ± 0.96 μg/mL). All new molecules were characterized by 1 H NMR, 13 C NMR, and MS.