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Recent Synthetic Approaches Towards Biologically Potent Derivatives/Analogues of Theophylline
Author(s) -
Yousaf Muhammad,
Zahoor Ameer Fawad,
Faiz Sadia,
Javed Sadia,
Irfan Muhammad
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3311
Subject(s) - theophylline , chemistry , bronchodilator , biological activity , antifungal , purine , pulmonary disease , pharmacology , asthma , combinatorial chemistry , biochemistry , in vitro , enzyme , medicine , dermatology
Theophylline, also known as 1,3‐dimethylxanthine, belongs to class of purine‐based drugs, which are used in the treatment of air ways disorders such as asthma and chronic obstructive pulmonary disease. Its derivatives play a significant role in the variety of biological applications of medicinal interest as it exhibits numerous activities such as anticancer, anti‐inflammatory, bronchodilator activity, antibacterial, and antifungal activities. This review article summarizes the recent advances in the synthesis of theophylline derivatives, which were reported during 2008–2017, and also describes the detailed biological studies of synthesized analogues.