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Hantzsch Reaction: A Greener and Sustainable Approach to 1,4‐Dihydropyridines Using Non‐commercial β‐Ketoesters
Author(s) -
Dharma Rao G. B.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3309
Subject(s) - chemistry , transesterification , ammonium carbonate , catalysis , alcohol , organic chemistry , aqueous medium , reaction conditions , carbonate , aqueous solution , green chemistry , reaction mechanism , nuclear chemistry
An expeditious synthesis of new series of symmetrical 1,4‐dihydropyrimidine derivatives has been developed using a four‐component reaction involving the in situ generation of non‐commercial β‐ketoesters via transesterification transformation of tert ‐butyl‐β‐ketoester with corresponding alcohol followed by the one‐pot Hantzsch reaction with arylaldehyde and ammonium carbonate in aqueous medium at 70°C under catalyst‐free conditions.