Molecular Modeling, Ionic Liquid Cu(II)‐Catalyzed Synthesis of 9‐(3‐Fluoro‐4‐methoxyphenyl)‐6‐aryl‐[1,2,4]triazolo[4,3‐ a ][1,8] Naphthyridines under Microwave Irradiation and Their Antimicrobial Activity

A highly efficient and simple procedure has been developed for the synthesis of 9‐(3‐fluoro‐4‐methoxyphenyl)‐6‐aryl‐[1,2,4]triazolo[4,3‐ a ][1,8] naphthyridines by ionic liquid Cu(II) oxidative cyclization of 2‐(2‐(3‐fluoro‐4‐methoxybenzylidene)hydrazinyl)‐3‐phenyl‐1,8‐naphthyridine under microwave irradiation. Synthesized compounds have been described by microanalysis, infrared, 1 H NMR spectroscopy, and mass spectrometry. Sixteen of the synthesized compounds were evaluated for their antimicrobial activity against bacteria, such as Staphylococcus aureus , Bacillus subtilis , Escherichia coli , and Klebsiella pneumoniae , as well as fungi, such as Aspergillus flavus and Fusarium oxysporum . Results of the antimicrobial screening showed that the compounds 3b , 3g , and 3j have maximal zones of inhibition against the tested bacterial strains. Docking studies were carried out for the three most active compounds 3b , 3g , and 3j along with the inactive compound 3a .