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Efficient synthesis of 1,2,4‐triazolo[4,3‐ a ][1,8]naphthyridines under microwave irradiation
Author(s) -
Mogilaiah K.,
Swamy T. Kumara,
Kumar K. Shiva
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.33
Subject(s) - chemistry , microwave irradiation , methanol , aryl , irradiation , microwave , combinatorial chemistry , nuclear chemistry , organic chemistry , catalysis , alkyl , physics , quantum mechanics , nuclear physics
A simple and highly efficient procedure has been described for the synthesis of 6‐aryl‐9‐(4‐phenoxphenyl)‐1,2,4‐triazolo [4,3‐a] [1,8] napthyridines (4) by the oxidation of 4‐phenoxybenzaldehyde 3‐aryl‐1,8‐naphthyridin‐2‐ylhydrazones (3) with chloramines‐T in methanol under microwave irradiation. The products were obtained in very good yields and excellent purities. J. Heterocyclic Chem., 46 , 124 (2009).