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Synthesis of Novel Bis(thiazolylchromen‐2‐one) Derivatives Linked to Alkyl Spacer via Phenoxy Group
Author(s) -
Hosny Mohamed,
Salem Mostafa E.,
Darweesh Ahmed F.,
Elwahy Ahmed H. M.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3296
Subject(s) - chemistry , alkyl , medicinal chemistry , reaction conditions , elemental analysis , group (periodic table) , spectral properties , stereochemistry , organic chemistry , computational chemistry , catalysis
A novel series of bis(thiazolylchromen‐2‐one) derivatives 8 were prepared in good yields by the reaction of the appropriate bis(α‐bromoketones) 7 with 2‐(1‐(2‐oxo‐2 H ‐chromen‐3‐yl)ethylidene) hydrazinecarbothioamide ( 6 ) in refluxing EtOH in the presence of few drops of TEA. Some other isomeric derivatives of bis(thiazolylchromen‐2‐one) 11 and 13 were also successfully obtained by the reaction of bromoacetylcoumarin 9 with the corresponding bis(ethan‐1‐yl‐1‐ylidene))bis(hydrazinecarbothioamides) 10 and 12 . The structures of the new compounds were established based on elemental analyses as well as spectral data.