Premium
Studies on the Chemical Reactions of Some 3‐Substituted‐6,8‐dimethylchromones with Nucleophilic Reagents
Author(s) -
Ibrahim Magdy A.,
Badran AlShimaa,
ElGohary Nasser M.,
Hashiem Salsabeel H.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3291
Subject(s) - chemistry , nucleophile , reagent , reactivity (psychology) , cyanoacetamide , combinatorial chemistry , organic chemistry , nucleophilic addition , catalysis , medicine , alternative medicine , pathology
A variety of 3‐substituted‐6,8‐dimethylchromones have been synthesized and characterized. The chemical reactivity of 3‐substituted‐6,8‐dimethylchromones was studied towards some nucleophiles, namely, S ‐benzyldithiocarbazate, o ‐phenylenediamine, and cyanoacetamide, and a diversity of products were efficiently synthesized. Reactions of 3‐substituted‐6,8‐dimethylchromones (except 3‐formyl‐6,8‐dimethylchromone), with nucleophilic reagents, usually proceed through nucleophilic attack at C‐2 position followed by different types of heterocyclization depending on the functional group present at C‐3 position. Structures of the newly synthesized products have been established based on elemental analysis and spectral data.