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Synthesis, Molecular Docking, and Biological Evaluation of Some Novel Bis‐heterocyclic Compounds Based N , N ′‐([1,1′‐biphenyl]‐4,4′‐diyl)bis(2‐cyanoacetamide) as Potential Anticancer Agents
Author(s) -
Metwally Nadia Hanafy,
Abdelrazek Fathy Mohamed,
Eldaly Salwa Magdy
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3290
Subject(s) - chemistry , biphenyl , thiazole , in vitro , doxorubicin , stereochemistry , moiety , cervical carcinoma , combinatorial chemistry , hepatocellular carcinoma , benzimidazole , pharmacology , biochemistry , cancer , cancer research , organic chemistry , cervical cancer , chemotherapy , medicine , biology , surgery
Synthesis of unreported hitherto N , N ′‐([1,1′‐biphenyl]‐4,4′‐diyl)bis(2‐cyanoacetamide) as a precursor to synthesize bis‐chromenes, bis‐thiazole derivatives, and bis‐pyridizines. The structures of the newly synthesized compounds were established by their elemental analyses and spectral data. Some of the newly synthesized compounds were tested for in vitro activity against hepatocellular carcinoma, human breast cancer, and human cervical carcinoma cell lines compared with the employed standard antitumor drug (doxorubicin), and the results revealed that the starting N , N ′‐([1,1′‐biphenyl]‐4,4′‐diyl)bis(2‐cyanoacetamide) is more potent activity than doxorubicin against hepatocellular carcinoma and human cervical carcinoma.