Dipyrido[1,2‐b:3′,4′‐e][1,2,4]triazine Scaffolds from Pentafluoropyridine

Annelation reaction between pentafluoropyridine and diaminodihydro substituted pyridine derivatives gave dipyrido[1,2‐b:3′,4′‐e][1,2,4]triazine systems as major products arising from the initial nucleophilic substitution of more nucleophilic N ‐amino group of pyridone ring at 4‐position of the pyridine ring followed by intramolecular cyclization at 3‐position of pyridine ring. Also, 6‐amino‐2‐oxo‐1‐((perfluoropyridin‐4‐yl)amino)‐4‐aryl‐1,2‐dihydropyridine‐3,5‐dicarbonitrile derivatives were obtained as side products. The structures of all the compounds were confirmed by IR, 1 H NMR, 13 C NMR, and 19 F NMR spectroscopy as well as elemental analysis.