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Design, Synthesis, and Antibacterial Evaluation of Propylene‐tethered 8‐Methoxyl Ciprofloxacin‐isatin Hybrids
Author(s) -
Guo Hua
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3279
Subject(s) - isatin , chemistry , ciprofloxacin , antibacterial activity , hybrid , gram , minimum inhibitory concentration , bacteria , in vitro , stereochemistry , antibiotics , organic chemistry , biochemistry , botany , biology , genetics
A series of 8‐methoxyl ciprofloxacin (8‐OMe CPFX)‐isatin hybrids 3a – f and 4a – f tethered through propylene were designed, synthesized, and examined for their in vitro antibacterial activities against a panel of Gram‐positive and Gram‐negative pathogens including drug‐resistant bacteria. All the synthesized hybrids (minimum inhibitory concentration: ≤0.03–64 μg/mL) exhibited considerable activities against the tested strains, especially against the Gram‐negative pathogens. Among them, hybrid 3b was no inferior to the parent 8‐OMe CPFX that could act as a starting point for further optimization.