Design, Synthesis, and Antibacterial Evaluation of Propylene‐tethered 8‐Methoxyl Ciprofloxacin‐isatin Hybrids

A series of 8‐methoxyl ciprofloxacin (8‐OMe CPFX)‐isatin hybrids 3a – f and 4a – f tethered through propylene were designed, synthesized, and examined for their in vitro antibacterial activities against a panel of Gram‐positive and Gram‐negative pathogens including drug‐resistant bacteria. All the synthesized hybrids (minimum inhibitory concentration: ≤0.03–64 μg/mL) exhibited considerable activities against the tested strains, especially against the Gram‐negative pathogens. Among them, hybrid 3b was no inferior to the parent 8‐OMe CPFX that could act as a starting point for further optimization.