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A Convenient Synthesis and Biological Research of Novel 5,6,7,8‐Tetrahydro‐1,6‐naphthyridin‐2(1 H )‐one Derivatives Hydrochloride as Cytotoxic Agents
Author(s) -
Xu Guiqing,
Gao Yuan,
Sun Bin,
Peng Lizeng,
Mao Longfei,
Jiang Yuqin,
Ding Qingjie
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3273
Subject(s) - chemistry , hydrochloride , cytotoxicity , stereochemistry , mass spectrometry , mtt assay , in vitro , high resolution , carbon 13 nmr , combinatorial chemistry , chromatography , organic chemistry , biochemistry , remote sensing , geology
A series of 5,6,7,8‐tetrahydro‐1,6‐naphthyridin‐2(1 H )‐one derivatives hydrochloride were obtained using a convenient and mild method from 4‐piperidone monohydrate hydrochloride. The newly synthesized compounds and their derivatives were characterized by 1 H NMR, 13 C NMR, and high‐resolution mass spectrometry. Furthermore, cytotoxicity in vitro of the synthesized compounds were screened using MTT or CCK8 assay. The results showed that some of the compounds showed potential antitumor activity. Among of them, compound 10a had effects against tumor cells (MOLM‐13), and the half maximal inhibitory concentration value was 76 μmol/L.