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Studies in synthesis of new psoralenamines
Author(s) -
Patel Jagdish M.,
Soman Shubhangi S.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.327
Subject(s) - chemistry , halogenation , potassium hydroxide , ring (chemistry) , psoralen , furan , organic chemistry , medicinal chemistry , dna , biochemistry
New amino psoralen derivatives have been synthesized via bromination . Bromination of 3,5‐substituted psoralens has been studied. The second position of the furan ring is more susceptible to bromination than the α‐position of the chromen‐2‐one ring in psoralens. Hence, the target psoralenamines were synthesized starting with 3‐bromo‐7‐hydroxy‐4‐methyl‐chromen‐2‐one, which was condensed with different α‐halo ketones and cyclized in ethanolic potassium hydroxide to get the desired 6‐bromo psoralens, which were finally converted into psoralenamines. J. Heterocyclic Chem., (2010).