Synthesis of 7‐Oxo‐1,2,3,4,6,7,12,12b‐octahydroindolo[2,3‐ a ]quinolizine | Zendy

Tompkins David C. | Zendy; Nelson Randall B. | Zendy; Dolby Lloyd J. | Zendy; Gribble Gordon W. | Zendy

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Synthesis of 7‐Oxo‐1,2,3,4,6,7,12,12b‐octahydroindolo[2,3‐ a ]quinolizine

Author(s) -

Tompkins David C.,

Nelson Randall B.,

Dolby Lloyd J.,

Gribble Gordon W.

Publication year - 2018

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3251

Subject(s) - chemistry , ring (chemistry) , alkaloid , derivative (finance) , stereochemistry , dimethylacetamide , phenylhydrazine , organic chemistry , solvent , financial economics , economics

A short synthesis of 7‐oxo‐1,2,3,4,6,7,12,12b‐octahydroindolo[2,3‐ a ]quinolizine from 2‐acetylpyridine and phenylhydrazine is described. Ring C is forged using 2‐chloro‐ N , N‐ dimethylacetamide. This derivative of the natural alkaloid 1,2,3,4,6,7,12,12b‐octahydroindolo[2,3‐ a ]quinolizine is an inhibitor of the ZipA–FtsZ protein–protein complex, which is a novel antibacterial target.

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