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Synthesis of 7‐Oxo‐1,2,3,4,6,7,12,12b‐octahydroindolo[2,3‐ a ]quinolizine
Author(s) -
Tompkins David C.,
Nelson Randall B.,
Dolby Lloyd J.,
Gribble Gordon W.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3251
Subject(s) - chemistry , ring (chemistry) , alkaloid , derivative (finance) , stereochemistry , dimethylacetamide , phenylhydrazine , organic chemistry , solvent , financial economics , economics
A short synthesis of 7‐oxo‐1,2,3,4,6,7,12,12b‐octahydroindolo[2,3‐ a ]quinolizine from 2‐acetylpyridine and phenylhydrazine is described. Ring C is forged using 2‐chloro‐ N , N‐ dimethylacetamide. This derivative of the natural alkaloid 1,2,3,4,6,7,12,12b‐octahydroindolo[2,3‐ a ]quinolizine is an inhibitor of the ZipA–FtsZ protein–protein complex, which is a novel antibacterial target.