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Synthesis of Novel Pyrazole–sucrose Derivatives by 1,3‐dipolar Cycloaddition
Author(s) -
Hajlaoui Khaoula,
El Guesmi Ahlem,
Ben Hamadi Naoufel,
Msaddek Moncef
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3246
Subject(s) - chemistry , regioselectivity , cycloaddition , pyrazole , enantiopure drug , propargyl , 1,3 dipolar cycloaddition , furan , aryl , organic chemistry , combinatorial chemistry , catalysis , enantioselective synthesis , alkyl
The syntheses of an important class of enantiopure five‐membered glyconjucates containing furan unit are described. The regioselective synthesis of a series of sugar‐fused pyrazole heterocycles was achieved by the Huisgen cyclization of aryl diazomethanes with propargyl O ‐glycoside derivatives in good yields. The cycloaddition regioselectivity was confirmed by NMR.
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