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Design, Synthesis, and In Vitro Antibacterial Activities of Propylene‐tethered Gatifloxacin‐isatin Hybrids
Author(s) -
Guo Hua
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3226
Subject(s) - isatin , gatifloxacin , chemistry , antibacterial activity , in vitro , gram , combinatorial chemistry , organic chemistry , biochemistry , bacteria , biology , antibiotics , ciprofloxacin , genetics
A series of novel mono‐/bis‐isatin‐gatifloxacin hybrids 3a–f and 4a–f tethered through propylene were designed, synthesized, and evaluated for their in vitro antibacterial activities against representative Gram‐positive and Gram‐negative pathogens. The results indicated that all mono‐isatin‐gatifloxacin hybrids exhibited considerable antibacterial activities with minimum inhibitory concentration ranging from 0.06 to 4 μg/mL against the majority of the tested strains. In particular, the mono‐isatin‐gatifloxacin hybrid 3b was found as potent as the parent gatifloxacin against Gram‐positive organisms and could act as a starting point for further optimization.