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Microwave‐Assisted Synthesis and Characterization of Novel Sulfonamide‐β‐Lactam Conjugates
Author(s) -
Brown David P.,
Saklani Pooja,
Luo Jiawei
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3219
Subject(s) - chemistry , sulfonamide , lactam , conjugate , microwave irradiation , combinatorial chemistry , microwave , stereochemistry , organic chemistry , catalysis , physics , quantum mechanics , mathematical analysis , mathematics
New sulfonamide‐β‐lactam molecular conjugates 3 ( a – l ) have been generated through microwave‐assisted synthesis. β‐Lactams 1 ( a – e ) reacted with selected sulfonamides under microwave irradiation in the presence of KI and mediated by K 2 CO 3 to afford conjugates 3 ( a – l ). All new compounds were structurally authenticated by spectroscopic and elemental analyses.