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Design, Synthesis and Computational Studies of Novel Carbazole N‐phenylacetamide Hybrids as Potent Antibacterial, Anti‐inflammatory, and Antioxidant Agents
Author(s) -
Pattanashetty Shivarudrappa H.,
Hosamani K. M.,
Shettar Arun Kashivishwanath,
Mohammed Shafeeulla R.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3214
Subject(s) - chemistry , bacillus subtilis , antibacterial activity , carbazole , pseudomonas aeruginosa , antioxidant , escherichia coli , staphylococcus aureus , docking (animal) , substituent , in vitro , minimum inhibitory concentration , in silico , combinatorial chemistry , stereochemistry , bacteria , biochemistry , organic chemistry , biology , medicine , genetics , nursing , gene
The present study deals with the synthesis of N‐phenylacetamide‐functionalized carbazole derivatives and their antibacterial, anti‐inflammatory, and antioxidant assays. In vitro antibacterial studies of synthesized compounds shows prominent activity against Staphylococcus aureus , Bacillus subtilis , Escherichia coli , and Pseudomonas aeruginosa . In addition, in silico molecular docking studies corroborated that the methyl substituent ( 3g ), ( 3h ), and ( 3i ) showed promising activity with lower ∆G (kcal/mol) values. This study envisages that these compounds can serve as a new leading template in the chemotherapy of various bacterial ailments.