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Synthesis and Spectroscopic Characterization of Some Hydrazone and 2 H ‐benzopyranone Derivatives as Antitumor Agents
Author(s) -
Abumelha Hana M. A.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3211
Subject(s) - hydrazone , chemistry , cytotoxicity , carboxamide , stereochemistry , alkyl , carboxylate , proton nmr , combinatorial chemistry , medicinal chemistry , organic chemistry , in vitro , biochemistry
A new series of hydrazone, 2 H ‐benzopyranone‐3‐carboxamide and 2 H ‐benzopyranone‐3‐carbonylthiosemicarbazide derivatives were synthesized from the alkyl 7‐hydroxy‐2 H ‐benzopyranone‐3‐carboxylate ( 1a , b ) and dibromo derivatives ( 6a , b ) as a key starting materials. The structures of the synthesized new compounds were confirmed by IR , 1 H , 13 C‐NMR , MS , and elemental analysis. Some hydrazone derivatives and N ‐substituted 2 H ‐benzopyranone‐3‐carboxamides were evaluated for their anticancer activity against HepG‐2 cell lines. Some of these compounds shared good cytotoxicity.