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Synthesis of some new Pyridine‐based Heterocyclic Compounds with Anticipated Antitumor Activity
Author(s) -
Gomha Sobhi M.,
Abdelrazek Fathy M.,
Abdelrahman Aly H.,
Metz Peter
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3210
Subject(s) - chemistry , pyridine , pyrazole , elemental analysis , medicinal chemistry , halide , combinatorial chemistry , organic chemistry
A novel class of 5‐amino‐ N′ ‐(1‐(pyridin‐4‐yl)ethylidene)‐1 H ‐pyrazole‐4‐carbohydrazides and 8‐(pyridin‐4‐yl)pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidin‐5(1 H )‐ones was synthesized from reaction of 2‐cyano‐ N ′‐(1‐(pyridin‐4‐yl)ethylidene)‐acetohydrazide and 7‐(pyridin‐4‐yl)‐2‐thioxo‐2,3‐dihydropyrido[2,3‐d]pyrimidin‐4(1 H )‐one with the appropriate hydrazonoyl halides. Moreover, 2‐cyano‐ N ′‐(1‐(pyridin‐4‐yl)‐ethylidene)‐acetohydrazide was used for the synthesis of 2‐cyano‐ N ′‐(1‐(pyridin‐4‐yl)ethylidene)‐acrylohydrazides and 2‐oxo‐2‐(2‐(1‐(pyridin‐4‐yl)ethylidene)‐hydrazinyl)‐acetohydrazonoyl cyanides. The structures of the newly prepared compounds were confirmed by both elemental and spectral analyses as well as by alternate synthesis. The anticancer activities of the prepared compounds were screened against the hepatocellular carcinoma (HepG2) cell line, and the results showed that most of the compounds exhibit considerable activities.