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Synthesis of new 1,2,3‐triazolo[1,5‐a]quinazolinones
Author(s) -
Pokhodylo Nazariy T.,
Matiychuk Vasyl S.
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.321
Subject(s) - acetonitriles , chemistry , benzothiazole , thiazole , reactivity (psychology) , domino , oxadiazole , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , acetonitrile , catalysis , medicine , alternative medicine , pathology
ynthesis of novel 3‐substituted‐1,2,3‐triazolo[1,5‐a]quinazolinones in high yields was performed via anionic hetero‐domino reaction of appropriate substituted 2‐azidobenzoates prepared from isatines and acetonitriles activated by 1,3‐thiazole, 1,3‐benzothiazole, 1,3,4‐oxadiazole, and 1,2,4‐oxadiazole rings. It was shown that acetonitriles exhibited high reactivity and were convenient methylenic compounds for such reactions providing rapid structural variation. J. Heterocyclic Chem., (2010).

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