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Synthesis and Antimicrobial Evaluation of (1‐(2‐(Benzyloxy)‐2‐oxoethyl)‐1 H ‐1,2,3‐triazol‐4‐yl)methyl Benzoate Analogues
Author(s) -
Kaushik C. P.,
Pahwa Ashima,
Kumar Devinder,
Kumar Ashwani,
Singh Dharmendra,
Kumar Krishan,
Luxmi Raj
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3209
Subject(s) - enterobacter aerogenes , chemistry , antimicrobial , aspergillus niger , klebsiella pneumoniae , candida albicans , staphylococcus aureus , proton nmr , escherichia coli , carbon 13 nmr , stereochemistry , benzoic acid , combinatorial chemistry , organic chemistry , microbiology and biotechnology , bacteria , biochemistry , genetics , biology , gene
A convenient one pot synthesis of 20 (1‐(2‐(benzyloxy)‐2‐oxoethyl)‐1 H ‐1,2,3‐triazol‐4‐yl)methyl benzoate analogues ( 5a – 5t ) with ester functionality was carried out via Cu(I) catalyzed click reaction between prop‐2‐yn‐1‐yl benzoates and benzyl 2‐azidoacetates. The structure of synthesized triazoles were explicated by various spectral techniques like FT‐IR, 1 H NMR, 13 C NMR, and high‐resolution mass spectrometry and evaluated for in vitro antimicrobial potential against Staphylococcus aureus , Escherichia coli , Klebsiella pneumoniae , Enterobacter aerogenes , Candida albicans , and Aspergillus niger . Most of synthesized triazole derivatives exhibited average to excellent activity against tested microbial strains.