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Synthesis and in vitro Biological Evaluation of Some Novel Triazole‐Based Heterocycles as Potential Antimicrobial Agents
Author(s) -
Sahi Seema,
Sodhi Ravinderpal Kour,
Jamwal Babita,
Paul Satya
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3193
Subject(s) - moiety , chemistry , antimicrobial , aryl , thiadiazoles , triazole , antifungal , stereochemistry , dept , in vitro , combinatorial chemistry , 1,2,4 triazole , antibacterial activity , bacteria , biological activity , organic chemistry , microbiology and biotechnology , biochemistry , alkyl , genetics , biology
A series of novel 6‐{5‐aryl‐4 H ‐1,2,4‐triazol‐3‐ylthio}methyl‐3‐substituted‐[1,2,4]triazolo[3,4‐ b ][1,3,4]thiadiazoles and 2‐{(5‐aryl‐4 H ‐1,2,4‐triazol‐3‐ylthio)‐ N ‐4‐aryl}acetamides containing 1,2,4‐triazole moiety were synthesized and characterized by 1 H, 13 C, DEPT, and D 2 O. The synthesized compounds were evaluated for their antibacterial activity against three strains of bacteria along with antifungal activity against five fungal species. It has been found that tested compounds showed moderate activity.