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Isatin Derivatives with Potential Antitubercular Activities
Author(s) -
Jiang Dan,
Wang GangQiang,
Liu Xiaofeng,
Zhang Zhenbin,
Feng LianShun,
Liu MingLiang
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3189
Subject(s) - isatin , mycobacterium tuberculosis , chemistry , tuberculosis , drug , first line , combinatorial chemistry , pharmacology , biology , medicine , organic chemistry , pathology
Tuberculosis is a life‐threatening chronic infectious disease, which primarily affects the lungs but can spread to other vital organs. The re‐emergence and wide spread of new virulent forms of Mycobacterium tuberculosis that are resistant to some or all first and second line antitubercular agents has reached an alarming level in recent decades. Thus, it is imperative to develop more effective agents. Isatin derivatives are endowed with diverse biological properties, therefore thousands of isatin derivatives have been synthesized in hopes of discovering new candidates with potential antitubercular activities against both drug‐susceptible and drug‐resistant strains. This review summarizes the recent developments of isatin derivatives with potential antitubercular activities.