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An efficient synthesis of 5,6‐dihydrobenzo[ h ]quinazoline derivatives under solvent‐free conditions
Author(s) -
Gao Lijiu,
Ji Honglou,
Rong Liangce,
Han Hongxia,
Shi Yanhui,
Tu Shujiang
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.318
Subject(s) - chemistry , quinazoline , solvent , environmentally friendly , urea , sodium hydroxide , organic chemistry , combinatorial chemistry , biology , ecology
An efficient and convenient method for the preparation of 5,6‐dihydrobenzo[ h ]quinazoline derivatives by the multicomponent reactions of aromatic aldehydes, 3,4‐dihydronaphthalen‐1(2 H )‐one and urea or acetamidine hydrochloride, in the presence of sodium hydroxide under solvent‐free conditions was reported. This method has the advantages of excellent yields, mild reaction conditions, easy work‐up, and environmentally friendly procedure. J. Heterocyclic Chem., (2010).