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Synthesis, Characterization, and Antioxidant Activity of a New Class of Amido linked Azolyl Thiophenes
Author(s) -
Thatha Sreenivasulu,
Ummadi Nagarjuna,
Venkatapuram Padmavathi,
Adivireddy Padmaja
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3177
Subject(s) - chemistry , antioxidant , thiophene , sonication , carboxamide , ring (chemistry) , polar effect , organic chemistry , medicinal chemistry , combinatorial chemistry , stereochemistry , chromatography
A new class of amido linked azolyl thiophenes was prepared from the synthetic intermediates azolyl amines and 5‐chlorothiophene‐2‐carbonyl chloride adopting conventional and ultrasonication methodologies. It was observed that the reaction took place in shorter reaction times with higher yields under ultrasonication. The structures of the synthesized compounds were characterized by spectral parameters and also tested for antioxidant activity. Among all the tested compounds, methoxy substituted oxazolyl thiophene carboxamide ( 8c ) displayed promising antioxidant activity. Besides, the electron donating groups on the phenyl ring enhanced the antioxidant activity when compared with the electron withdrawing groups.