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Regioselective Synthesis and Antibacterial Activity Studies of 1,2,3‐Triazol‐4‐YL]‐4‐methyl‐2H‐chromen‐2‐ones
Author(s) -
Kolichala Niranjan,
Thummala Bhupalreddy,
Karkala Vasantha Kumar Pai
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3175
Subject(s) - chemistry , coumarin , regioselectivity , antibacterial activity , azide , molecule , combinatorial chemistry , spectral analysis , elemental analysis , organic chemistry , stereochemistry , bacteria , catalysis , spectroscopy , physics , quantum mechanics , biology , genetics
Synthesis, spectral analysis, and antibacterial activity of new coumarin derivatives are described in this paper. Twelve new coumarin derivatives were synthesized in moderate to good yields by the react with 4‐methyl‐6‐(prop‐2‐ynyloxy)‐2 H ‐chromen‐2‐one ( 3a – c ) and ethyl azide ( 4a – l ) and done by the click reaction to obtained 6‐[(l‐ethyl‐l H ‐l,2,3‐triazol‐4‐yl)methoxy]‐4‐methyl‐2 H ‐chromen‐2‐ones ( 5a – l ). The structures of all the newly synthesized molecules were assigned by elemental analysis and spectral data. The synthesized compounds were screened for their antibacterial activities strains using Cup plate method.