Premium
Synthesis of Some Novel Thiazolo[3,2‐a]pyrimidine and Pyrimido[2,1‐b][1,3]thiazine Derivatives and their Antimicrobial Evaluation
Author(s) -
Behalo Mohamed S.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3174
Subject(s) - chemistry , thiazine , pyrimidine , antimicrobial , acetic acid , antifungal , elemental analysis , mass spectrum , antibacterial activity , proton nmr , stereochemistry , combinatorial chemistry , organic chemistry , bacteria , medicine , ion , dermatology , biology , genetics
A 2‐(2‐Mercapto‐4‐(4‐phenoxyphenyl)‐6‐(thiophen‐2‐yl)‐1,6‐dihydropyrimidin‐5‐yl) acetic acid was used as a reactive key precursor to design various pyrimidine derivatives such as thiazolo[3,2‐a]pyrimidines and pyrimido[2,1‐b][1,3]thiazines. The chemical structures of the newly synthesized products were confirmed by their elemental analyses and spectral data (IR, 1 H NMR, 13 C NMR, and mass spectra). The antibacterial and antifungal activities of some of the synthesized products were also evaluated, and it was found that compounds 3, 5, 9 , and 11 exhibited potent activity against tested microorganisms in comparison with standard drugs.