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Synthesis, Characterization, and Antimicrobial Screening of 4″‐methyl‐2,2″‐diaryl‐4,2′:4′,5″‐terthiazole Derivatives
Author(s) -
Nalawade Jitendra,
Mhaske Pravin C.,
Shinde Abhijit,
Patil Sachin V.,
Choudhari Prafulla B.,
Bobade Vivek D.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3170
Subject(s) - bacillus subtilis , antimicrobial , chemistry , antibacterial activity , staphylococcus aureus , minimum inhibitory concentration , escherichia coli , in vitro , antifungal , bacteria , microbiology and biotechnology , combinatorial chemistry , organic chemistry , biochemistry , biology , genetics , gene
A series of novel 4″‐methyl‐2,2″‐diaryl‐4,2′:4′,5″‐terthiazole ( 8a‐p ) derivatives has been synthesized and screened for antibacterial activity against four pathogenic bacteria, Escherichia coli , Pseudomonas flurescence , Staphylococcus aureus , and Bacillus subtilis . Among them, compounds 8a and 8j exhibited excellent antibacterial activity with minimum inhibitory concentration range of 1.0 to 5.3 μg/mL and compounds 8m and 8p exhibited moderate to good antibacterial activity with minimum inhibitory concentration range of 16.9 to 29.7 μg/mL against all tested strains. All the synthesized compounds were screened for their in vitro antifungal activity against Cocinida candida . Most of the compounds reported moderate antifungal activity. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimicrobial agent.