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Catalyst‐free Synthesis of Tetrahydroacenaphtho[1,2‐ b ]indolone Derivatives via One‐pot Four‐component Reaction
Author(s) -
Bayat Mohammad,
Amiri Zeinab
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3167
Subject(s) - dimedone , chemistry , catalysis , methylene , ethanol , component (thermodynamics) , organic chemistry , combinatorial chemistry , physics , thermodynamics
A simple and efficient one‐pot synthesis of tetrahydroacenaphtho[1,2‐ b ]indolone derivatives via four‐component reaction of 5,5‐dimethylcyclohexane‐1,3‐dione (dimedone), arylamines, acenaphthoquinone, and active methylene compounds under catalyst‐free conditions is described. The reactions were carried out under mild conditions using ethanol as solvent. Advantages of this method include simple experimental and workup procedure, readily available starting materials, and high yields.