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Synthesis of 2‐amino‐4‐(2‐ethoxybenzo[d][1,3]dioxol‐5‐yl)‐4 H ‐pyran‐3‐Carbonitrile Derivatives and Their Biological Evaluation
Author(s) -
Baitha Amresh,
Gopinathan Ajay,
Krishnan Kartik,
Dabholkar Vijay V.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3152
Subject(s) - chemistry , pyran , imidazole , catalysis , amino acid , antimicrobial , combinatorial chemistry , organic chemistry , medicinal chemistry , stereochemistry , biochemistry
A new class of substituted 2‐amino‐4‐(2‐ethoxybenzo[d][1,3]dioxol‐5‐yl)‐4H‐pyran‐3‐carbonitrile derivatives catalyzed by Imidazole under mild reaction conditions has been developed. A variety of functionalized 2‐amino‐4‐(2‐ethoxybenzo[d][1,3]dioxol‐5‐yl)‐4H‐pyran‐3‐carbonitrile scaffolds were assembled in high yields by this catalytic protocol. The newly synthesized compounds have been characterized by IR, 1 H NMR, 13 C NMR, and mass spectral data. The compounds were then evaluated for antimicrobial activities.