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Enhancement of Different Biomedical Activities of Newly Synthesized Quinazoline Derivatives
Author(s) -
Zeid Ibrahim F.,
Kassem Emad M.,
Mohamed Neama A.,
Salman Ahmed A.,
Shalaby Al Shimaa G.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3147
Subject(s) - chemistry , candida albicans , antimicrobial , aspergillus niger , pathogenic bacteria , antibacterial activity , staphylococcus aureus , quinazolinone , klebsiella pneumoniae , pseudomonas aeruginosa , quinazoline , bacteria , escherichia coli , streptococcus pneumoniae , microbiology and biotechnology , stereochemistry , organic chemistry , antibiotics , biochemistry , genetics , gene , biology
A series of newly synthesized compounds of quinazolinone by various substituents was screened for its pharmacological activities. These included their action as antibacterial agents against pathogenic bacteria ( Staphylococcus aureus , Streptococcus pneumoniae , Escherichia coli , Klebsiella pneumoniae , and Pseudomonas aeruginosa ) and as antifungal agents against Aspergillus niger and pathogenic yeast ( Candida albicans ). The presently investigated compounds were synthesized in higher yields, and the structure features were elucidated on the basis of IR, 1 H‐NMR, and mass and elemental analysis data. These compounds were also evaluated as antioxidant agent. The results revealed that six compounds ( 2a , 11b , 11a , 2b , 13a , and 3c ) exhibited higher antimicrobial activity against the tested pathogenic strains. In addition, it was found that compound 6a exhibited a radical scavenging activity higher than other studied compounds.