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Synthesis of Novel β‐Lactams from Phenothiazin‐10‐ylacetic Acid
Author(s) -
Omidvari Zahra,
Zarei Maaroof
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3138
Subject(s) - chemistry , phenothiazine , ketene , imine , acetic acid , lactam , staudinger reaction , cycloaddition , proton nmr , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , medicine , pharmacology
The first synthesis of 3‐phenothiazine‐β‐lactams is herein reported. Thirteen new derivatives of β‐lactams were synthesized using various Schiff bases and (phenothiazin‐10‐yl)acetic acid, which in turn was prepared starting from phenothiazine. The sole product of the Staudinger ketene–imine [2 + 2] cycloaddition reaction is the trans ‐β‐lactam. All the synthesized compounds were characterized by elemental analyses and spectral (IR, 1 H‐NMR, and 13 C‐NMR) data.