Synthesis of Benzazolyl Pyrimidines Under Ultrasonication and Their Antimicrobial Activity | Zendy

Kayathi Narendra Babu | Zendy; Sowmya Donthamsetty V. | Zendy; Adivireddy Padmaja | Zendy; Venkatapuram Padmavathi | Zendy

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Synthesis of Benzazolyl Pyrimidines Under Ultrasonication and Their Antimicrobial Activity

Author(s) -

Kayathi Narendra Babu,

Sowmya Donthamsetty V.,

Adivireddy Padmaja,

Venkatapuram Padmavathi

Publication year - 2018

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3134

Subject(s) - chemistry , pyridine , antimicrobial , sonication , aspergillus niger , triethylamine , bacillus subtilis , minimum inhibitory concentration , nitro , polar effect , medicinal chemistry , nuclear chemistry , organic chemistry , bacteria , biochemistry , chromatography , alkyl , biology , genetics

(1) The benzoxazolyl/benzothiazolyl/benzimidazolyl pyrimidines were prepared under ultrasonication in the presence of pyridine/dimethylaminopyridine and triethylamine. (2) Better yields were recorded in 4‐( N , N ‐dimethylamino)pyridine and Et 3 N. (3) The presence of electron withdrawing chloro, bromo, and nitro substituents enhanced antimicrobial activity ( 13c , 13e , 14e : minimum inhibitory concentration = 6.25 μg/well against Bacillus subtilis ; 13e , 14e : minimum inhibitory concentration = 6.25 μg/well against Aspergillus niger ) .

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