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Synthesis of Benzazolyl Pyrimidines Under Ultrasonication and Their Antimicrobial Activity
Author(s) -
Kayathi Narendra Babu,
Sowmya Donthamsetty V.,
Adivireddy Padmaja,
Venkatapuram Padmavathi
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3134
Subject(s) - chemistry , pyridine , antimicrobial , sonication , aspergillus niger , triethylamine , bacillus subtilis , minimum inhibitory concentration , nitro , polar effect , medicinal chemistry , nuclear chemistry , organic chemistry , bacteria , biochemistry , chromatography , alkyl , biology , genetics
(1) The benzoxazolyl/benzothiazolyl/benzimidazolyl pyrimidines were prepared under ultrasonication in the presence of pyridine/dimethylaminopyridine and triethylamine. (2) Better yields were recorded in 4‐( N , N ‐dimethylamino)pyridine and Et 3 N. (3) The presence of electron withdrawing chloro, bromo, and nitro substituents enhanced antimicrobial activity ( 13c , 13e , 14e : minimum inhibitory concentration = 6.25 μg/well against Bacillus subtilis ; 13e , 14e : minimum inhibitory concentration = 6.25 μg/well against Aspergillus niger ) .