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Efficient Synthesis of New Benzofuran‐based Thiazoles and Investigation of their Cytotoxic Activity Against Human Breast Carcinoma Cell Lines
Author(s) -
Gomha Sobhi M.,
Abdelhamid Abdou O.,
Abdelrehem Nadia A.,
Kandeel Sahar M.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3131
Subject(s) - benzofuran , chemistry , thiazole , human breast , mcf 7 , combinatorial chemistry , alkoxy group , stereochemistry , cytotoxic t cell , doxorubicin , organic chemistry , biochemistry , breast cancer , cancer , chemotherapy , medicine , in vitro , alkyl
A new series of 1,3‐thiazole‐benzofuran derivatives was synthesized via heterocyclization of 2‐(1‐(6‐alkoxy‐4,7‐dimethoxybenzofuran‐5‐yl)ethylidene)‐2‐methyl‐2l4‐diazane‐1‐carbothioamides with hydrazonoyl halides. Also, 1‐(4,7‐dimethoxybenzofuran‐5‐yl)‐3‐phenylprop‐2‐en‐1‐one derivatives were used for synthesis of another series of 1,3‐thiazole‐pyrazole‐benzofuran. The structure of the newly synthesized products was elucidated via elemental analysis, spectral data, and alternative routes whenever possible. Seven new compounds were evaluated for their anticancer activity against the human breast carcinoma (MCF‐7) cell lines compared with doxorubicin drug. The results revealed that some new compounds showed promising anticancer activity.