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An Efficient One‐Pot Synthesis of Highly Substituted Pyridone Derivatives and Their Antimicrobial and Antifungal Activity
Author(s) -
Pandit Archana B.,
Savant Mahesh M.,
Ladva Kartik D.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3128
Subject(s) - chemistry , antimicrobial , 2 pyridone , yield (engineering) , cyanoacetamide , antifungal , gram , escherichia coli , bacteria , combinatorial chemistry , gram negative bacteria , organic chemistry , microbiology and biotechnology , biochemistry , materials science , genetics , gene , metallurgy , biology
A series of carboxamide and cyano functionalized pyridone derivatives 4a – q have been synthesized via one‐pot synthesis of various aldehydes 1a – q , acetoacetanilide 2 , and cyanoacetamide 3 . The reaction was simple and afforded pyridone derivatives in good yield, 89 to 93%. The novel pyridone derivatives were achieved by Hantzch one‐pot synthesis. Moreover, the synthesized compounds were screened against Gram‐positive and Gram‐negative bacteria and fungi for their activity. Among them, compound 4c shows highest inhibition at 4.25 mm against Staphylococcus aureus and 3.75 mm against Escherichia coli Gram‐positive and Gram‐negative bacteria, respectively.