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Synthetic Approach to Some New Annulated 1,2,4‐Triazine Skeletons with Antimicrobial and Cytotoxic Activities
Author(s) -
Hamama Wafaa S.,
ElBana Ghada G.,
Shaaban Saad,
Zoorob Hanafi H.
Publication year - 2018
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3127
Subject(s) - chemistry , antimicrobial , cytotoxic t cell , reagent , indole test , combinatorial chemistry , cancer cell lines , cancer cell , stereochemistry , organic chemistry , cancer , in vitro , biochemistry , medicine
The synthesis of some triazolotriazine, tetrazolotriazine, triazinotetrazine, and triazinotetrazepino‐indole by the reaction of 4‐amino‐6‐benzyl‐3‐hydrazinyl‐1,2,4‐triazin‐5(4 H )‐one ( 2 ) with different reagents is described. The synthesized compounds were screened for their antimicrobial activity using the minimum inhibition concentration method by serial dilution technique. Two of these compounds showed higher activity than that of standard drug, and they were further evaluated for their cytotoxic activities against human cancer cells (MCF‐7, HCT116, and HepG2), which indicate strong effect on these cancer cell lines.